System Biology and Bioinformatics

Research activities:

  • Deterministic and stochastic modelling of transcriptional networks and signaling pathways, reverse engineering of transcriptional networks and miRNA-mRNA regulatory motifs, and integration of genetic phenotypic and environmental risk factors via Systems Genetics approaches
  • Advanced data mining and machine learning methods for robust biomarker discovery, predictive modeling and clustering from microarrays and next generation sequencing  data

Homepage: http://sysbiobig.dei.unipd.it/

People: Barbara Di Camillo (contact person), Gianna Toffolo

  • Preprocessing and analysis of static and dynamic RNA-seq and microarray expression data.
  • Preprocessing of SNP arrays and exome sequencing data and multivariate analysis of genetic variations
  • Optimal primer design, pre-processing and analysis of 16S sequencing data and reverse engineering of microbial networks.
  • Methods for the preprocessing and quantification of mass spectrometry data and for the modeling of protein turnover from SILAC data.
  • Development and application of computational methods for genome reconstruction

Homepage: http://sysbiobig.dei.unipd.it/

People: Barbara Di Camillo (contact person), Gianna Toffolo