Fabio Scarpa - Publications


Papers in international journals:

A. Berto, F. Scarpa N. Tsiknakis, G. Manikis, D.I. Fotiadis, K. Marias, A. Scarpa (2023) “Automated analysis of fundus images for the diagnosis of retinal diseases: a review” . Research on Biomedical Engineering. doi: 10.1007/s42600-023-00320-9

A. Colonna, F. Scarpa (2023) “Improving corneal nerve segmentation using Tolerance Diceloss function” . Signal, Image and Video Processing. doi: 10.1007/s11760-023-02790-x

S.B.A. Mokhtar, F.C.T. van der Heide, K.A.M. Oyaert, C.J.H. van der Kallen, T.T.J.M. Berendschot, F. Scarpa, A. Colonna, B.E. de Galan, M.M.J. van Greevenbroek, P.C. Dagnelie, C.G. Schalkwijk, R.M.M.A. Nuijts, N.C. Schaper, A.A. Kroon, M.T. Schram, C.A.B. Webers, C.D.A. Stehouwer (2023) “(Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study” . Diabetologia 66:2030–204. doi: 10.1007/s00125-023-05986-5.

A. Colonna, F. Scarpa (2023) “Clinically Based Automated Tracing and Tortuosity Estimation of Corneal Nerve Fibers From Confocal Microscopy Images”. Cornea, 42:127–134. doi: 10.1097/ICO.0000000000003148.

N. Riva, F. Bonelli, R.M. Lasagni Vitar, M. Barbariga, P. Fonteyne, I.D. Lopez, T. Domi, F. Scarpa, A. Ruggeri, M. Reni, M. Marcatti, A. Quattrini, F. Agosta, P. Rama, G. Ferrari (2022) “Corneal and Epidermal Nerve Quantification in Chemotherapy Induced Peripheral Neuropathy”. Frontiers in Medicine, 9. doi: 10.3389/fmed.2022.832344.

R.A. Badian, S. Allgeier, F. Scarpa, M. Andréasson, A. Bartschat, R. Mikut, A. Colonna, M. Bellisario, T. Paaske Utheim, B. Köhler, P. Svenningsson, N. Lagali (2021) “Wide-field mosaics of the corneal subbasal nerve plexus in Parkinson´s disease using in vivo confocal microscopy”. Nature Scientific Data, 8, 306. doi: 10.1038/s41597-021-01087-3.

B. Nitzsche, W.W. Rong, A. Goede, B. Hoffmann, F. Scarpa, W.M. Kuebler, T.W. Secomb, A.R. Pries (2021) “Coalescent angiogenesis-evidence for a novel concept of vascular network maturation”. Angiogenesis. doi: 10.1007/s10456-021-09824-3.

N. Tsiknakis, D. Theodoropoulos, G. Manikis, E. Ktistakis, O. Boutsora, A. Berto, F. Scarpa, A. Scarpa, D.I. Fotiadis, K. Marias (2021) “Deep Learning for Diabetic Retinopathy Detection and Classification Based on Fundus Images: A Review”. Computers in Biology and Medicine. doi: 10.1016/j.compbiomed.2021.104599.

M. Andreasson, N. Lagali, R.A. Badian, T.P. Utheim, F. Scarpa, A. Colonna, S. Allgeier, A. Bartschat, B. Kohler, R. Mikut, K-M. Reichert, G. Solders, K. Samuelsson, H. Zetterberg, K. Blennow, P. Svenningsson (2021) “Parkinson's disease with restless legs syndrome – an in vivo corneal confocal microscopy study”. Nature Communications, 7(1):4. doi: 10.1038/s41531-020-00148-5.

F. Scarpa, A. Colonna, A. Ruggeri (2020) “Multiple-image deep learning analysis for neuropathy detection in corneal nerves images”. Cornea, vol 39(3), pp.342–347. doi: 10.1097/ICO.0000000000002181

M. Rubega, F. Scarpa, D. Teodori, A.S. Sejling, C. Frandsen, G. Sparacino (2020) “Detection of hypoglycemia using measures of EEG complexity in type 1 diabetes patients”. Entropy, vol. 22(81), pp.1–13.doi: 10.3390/e22010081.

F. Scarpa, M. Rubega, M. Zanon, F. Finotello, A.S. Sejling, G. Sparacino (2017) “Hypoglycemia-induced EEG complexity changes in Type 1 diabetes assessed by fractal analysis algorithm”. Biomedical Signal Processing and Control, vol 38, pp.168–173. doi: 10.1016/j.bspc.2017.06.004

F. Scarpa, A. Ruggeri (2016) “Development of a reliable automated algorithm for the morphometric analysis of human corneal endothelium”. Cornea, vol 35(9), pp.1222–1228. doi: 10.1097/ICO.0000000000000908

G. Ferrari, E. Grisan, F. Scarpa, R. Fazio, M. Comola, A. Quattrini, G. Comi, P. Rama, N. Riva (2014) “Corneal confocal microscopy reveals trigeminal small sensory fiber neuropathy in Amyotrophic Lateral Sclerosis”. Frontiers in Aging Neuroscience, vol 6(278). doi: 10.3389/fnagi.2014.00278

S. Brigadoi, L. Ceccherini, S. Cutini, F. Scarpa, P. Scatturin, J. Selb, L. Gagnon, D.A. Boas, R.J. Cooper (2014) “Motion artifacts in functional near–infrared spectroscopy: a comparison of motion correction techniques applied to real cognitive data”. NeuroImage, vol 85 (Part 1), pp. 181–191. doi: 10.1016/j.neuroimage.2013.04.082

F. Scarpa, S. Brigadoi, S. Cutini, P. Scatturin, M. Zorzi, R. Dell’Acqua, G. Sparacino (2013) “A Reference–Channel Based Methodology to Improve Estimation of Event Related Hemodynamic Response from fNIRS Measurements”. NeuroImage, vol 72, pp. 106–119. doi: 10.1016/j.neuroimage.2013.01.021

S. Cutini, F. Scarpa, P. Scatturin, R. Dell’Acqua, M. Zorzi (2014, first published online: 2012) “Number–Space Interactions in the Human Parietal Cortex: Enlightening the SNARC Effect with Functional Near–Infrared Spectroscopy”. Cerebral Cortex, vol 24(2), pp. 444-451. doi: 10.1093/cercor/bhs321

S. Brigadoi, S. Cutini, F. Scarpa, P. Scatturin, R. Dell’Acqua (2012) “Exploring the role of primary and supplementary motor areas in simple motor tasks with fNIRS”. Cognitive Processing, vol 13, n. 1, pp. 97–101. doi: 10.1007/s10339–012–0446–z

F. Scarpa, X. Zheng, Y. Ohashi, A. Ruggeri (2011) “Automatic Evaluation of Corneal Nerve Tortuosity in Images from In Vivo Confocal Microscopy”. Investigative Ophthalmology & Visual Science, vol 52, n. 9, pp. 6404–6408. doi: 10.1167/iovs.11–7259

S. Cutini, F. Scarpa, P. Scatturin, P. Jolicoeur, P. Pluchino, M. Zorzi, R. Dell’Acqua (2011) “A hemodynamic correlate of lateralized visual short–term memories”. Neuropsychologia, vol 49, pp. 1611–1621. doi: 10.1016/j.neuropsychologia.2010.12.009

F. Scarpa, S. Cutini, P. Scatturin, R. Dell’Acqua, G. Sparacino (2010) “Bayesian filtering of human brain hemodynamic activity elicited by visual short–term maintenance recorded through functional near–infrared spectroscopy (fNIRS)”. Optics Express, vol 18, n. 25, pp. 26550–26568. doi: 10.1364/OE.18.026550

A. Ruggeri, F. Scarpa, M. De Luca, C. Meltendorf, J. Schroeter (2010) “A system for the automatic estimation of morphometric parameters of corneal endothelium in alizarine red–stained images”. British Journal of Ophthalmology, vol 94, n. 5, pp. 643–647. doi: 10.1136/bjo.2009.166561

F. Scarpa, E. Grisan, A. Ruggeri (2008) “Automatic recognition of corneal nerve structures in images from confocal microscopy”. Investigative Ophthalmology & Visual Science, vol 49, n. 11, pp. 4801–4807. doi: 10.1167/iovs.08–2061


Papers in international conference proceedings:

A. Colonna, F. Scarpa, A. Ruggeri (2018) “Segmentation of Corneal Nerves Using a U-Net-Based Convolutional Neural Network” . In: Stoyanov D. et al. (eds) Computational Pathology and Ophthalmic Medical Image Analysis. OMIA 2018, COMPAY 2018. Lecture Notes in Computer Science, vol 11039. Springer, Cham. doi: 10.1007/978-3-030-00949-6_22

F. Scarpa, A. Ruggeri (2017) “Development of Clinically Based Corneal Nerves Tortuosity Indexes” . In: Cardoso M. et al. (eds) Fetal, Infant and Ophthalmic Medical Image Analysis. FIFI 2017, OMIA 2017. Lecture Notes in Computer Science, vol 10554. Springer, Cham, pp. 219–226. doi: 10.1007/978-3-319-67561-9_25

F. Scarpa, C. Dalla Gassa, A. Ruggeri (2016) “Automated Morphometric Analysis of in-vivo Human Corneal Endothelium”. Ophthalmic Medical Image Analysis Third International Workshop, OMIA 2016 - MICCAI 2016, Athens, Greece, October 21, pp. 89–96. doi: 10.17077/omia.1051

F. Scarpa, A. Ruggeri (2016) “Automated Morphometric Description of Human Corneal Endothelium from In-Vivo Specular and Confocal Microscopy”. 38th IEEE EMBS Annual International Conference, Orlando, FL, USA, August 16 – 20, pp. 1296–1299. doi: 10.1109/EMBC.2016.7590944

F. Scarpa, A. Ruggeri (2015) “Segmentation of Corneal Endothelial Cells Contour by Means of a Genetic Algorithm”. Ophthalmic Medical Image Analysis Second International Workshop, OMIA 2015 - MICCAI 2015, Munich, Germany, October 9, pp. 25–32. doi: 10.17077/omia.1023

F. Finotello, F. Scarpa, M. Zanon (2015) “EEG Signal Features Extraction based on Fractal Dimension”. 37th IEEE EMBS Annual International Conference, Milan, Italy, August 25 – 29, pp. 4154–4157. doi: 10.1109/EMBC.2015.7319309

F. Scarpa, C. Fabris, S. Brigadoi, S. Cutini, P. Scatturin, R. Dell’Acqua, G. Sparacino (2012) “A GLM–Based Approach to Estimate Stimulus–Evoked Hemodynamic Response from fNIRS Measurements”. 6th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), Shanghai, China, May 17 – 20, vol. 3, pp. 736–73

S. Brigadoi, F. Scarpa, S. Cutini, P. Scatturin, R. Dell’Acqua, M. Zorzi, G. Sparacino (2012) “Hemodynamic response estimation from fNIRS signal through a modeling approach exploiting the reference channel”. 6th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), Shanghai, China, May 17 – 20, vol. 3, pp. 661–664

F. Scarpa, S. Brigadoi, S. Cutini, P. Scatturin, M. Zorzi, R. Dell’Acqua, G. Sparacino (2011) “A Methodology to Improve Estimation of Stimulus–Evoked Hemodynamic Response from fNIRS Measurements”. 33rd IEEE EMBS Annual International Conference, Boston, MA, USA, August 30 – Sept 3, pp. 785–788. doi: 10.1109/IEMBS.2011.6090180

F. Scarpa, D. Fiorin, A. Ruggeri (2007) “In Vivo Three–Dimensional Reconstruction of the Cornea from Confocal Microscopy Images”. 29th IEEE EMBS Annual International Conference, Cité Internationale, Lyon, France, August 23 – 26, pp. 747–750. doi: 10.1109/IEMBS.2007.4352398

M. Martinello, P. Favaro, G. Muyo, A. Harvey, E. Grisan, F. Scarpa, A. Ruggeri (2007) “3–D Retinal Surface Inference: Stereo or Monocular Fundus Camera?”. 29th IEEE EMBS Annual International Conference, Cité Internationale, Lyon, France, August 23 – 26, pp. 896–899. doi: 10.1109/IEMBS.2007.4352435

A. Ruggeri, F. Scarpa, E. Grisan (2006) “Analysis of Corneal Images for the Recognition of Nerve Structures”. 28th IEEE EMBS Annual International Conference, New York City, New York, USA, August 30 – Sept. 3, pp. 4739–4742. doi: 10.1109/IEMBS.2006.259805


Book Chapters:

S. Cutini, F. Scarpa, P. Sessa, R. Dell’Acqua (2011) “Le tecniche di "neuroimaging"”. In: A. Zennaro Lo sviluppo della psicopatologia. pp. 86–108, BOLOGNA: il Mulino. ISSN/ISSN: 978–88–15–23256–4


Abstracts in international conference proceedings:

E. Candeo, A. Berto, G. Teza, A. Galgaro, F. Scarpa (2022) “3D Reconstruction and Analysis of Nevi for Melanoma Detection”. 44th IEEE EMBS Annual International Conference, Glasgow, Scotland, UK, July 11 – 15.

F. Scarpa, A. Berto, A. Colonna, A. Scarpa (2020) “Development of an automated analysis for glaucoma screening of videos acquired with smartphone ophthalmoscope”. ARVO annual meeting, Baltimore, MD, USA, May 3 – 7, Vol.61, 4542.

A. Colonna, F. Scarpa, R. Zorzan, C. Chao, R. Mobeen, B. Golebiowski, F. Stapleton, A. Ruggeri (2020) “Automatic identification of corneal epithelial dendritic cells via deep learning”. ARVO annual meeting, Baltimore, MD, USA, May 3 – 7, Vol.61, 4309.

B. Nitzsche, A. Goede, W.W. Rong, F. Scarpa, W.M. Kuebler, T.W. Secomb, A.R. Pries (2019) “Emerging angiogenesis in the microvascular bed of chick chorioallantoic membrane”. German Society for Microcirculation and Vascular Biology (GfMVB) annual meeting, Heidelberg, Germany, October 25 – 27

F. Scarpa, E. Candeo, M.G. Pedersen (2019) “Automated identification of secretory granules in TIRF images of pancreatic beta cells”. Biophysical Society, thematic meeting, Padova, Italy, May 6 – 10

F. Scarpa, A. Colonna, A. Ruggeri (2019) “Healthy vs pathological classification of corneal nerves images using deep learning”. ARVO annual meeting, Vancouver, Canada, April 28 – May 2

A. Colonna, F. Scarpa, A. Ruggeri (2019) “Automatic tracing of corneal sub-basal nerves using deep learning”. ARVO annual meeting, Vancouver, Canada, April 28 – May 2

F. Scarpa, A. Ruggeri (2018) “Differences in corneal nerves tortuosity indexes between healthy and diabetic subjects”. ARVO annual meeting, Honolulu, HI, USA, April 29 – May 3, n. 5718

F. Scarpa, P. Guimaraes, A. Ruggeri (2017) “Automatic grading of corneal sub-basal nerves tortuosities”. ARVO annual meeting, Baltimore, MD, USA, May 7 – 11, n. 3527

A. Ruggeri, F. Scarpa (2017) “Automatic estimation of optimal Region Of Interest for morphometry assessment in corneal endothelium images”. ARVO annual meeting, Baltimore, MD, USA, May 7 – 11, n. 3552

F. Scarpa, A. Ruggeri (2016) “Development of a totally automated method for the reliable morphometry of human corneal endothelium”. ARVO annual meeting, Seattle, WA, USA, May 1 – 6, n. 1935

A. Ruggeri, F. Scarpa (2015) “Computerized analysis of human corneal endothelium morphology”. European Association for Vision and Eye Research Conference, Nice, France, October 7 – 10. Acta Ophthalmologica, Volume 93, Issue Supplement S255. doi: 10.1111/j.1755-3768.2015.0551

F. Scarpa, A. Ruggeri (2015) “Automatic Segmentation of Corneal Endothelial Cells Contour”. 37th IEEE EMBS Annual International Conference, Milan, Italy, August 25 – 29

F. Scarpa, A. Ruggeri (2015) “Automatic segmentation of corneal endothelial cells by a genetic algorithm”. ARVO annual meeting, Denver, Colorado, USA, May 3 – 7, n. 1960

F. Scarpa, S. Brigadoi, S. Cutini, P. Scatturin, R. Dell’Acqua, G. Sparacino (2012) “Assessment of hemodynamic activity modulations: investigating visual short–term memory mechanisms through fNIRS and EEG”. Functional Near Infrared Spectroscopy: 2012, University College London, London, UK, October 26 – 28, pp. 135

S. Brigadoi, F. Scarpa, S. Cutini, P. Scatturin, R. Dell’Acqua, G. Sparacino (2011) “Development of a new method to reduce global physiological trends in fNIRS measures of brain activation”. Brain'11 & BrainPET'11, Barcelona, Spain, May 25 – 28

F. Scarpa, S. Cutini, P. Scatturin, R. Dell’Acqua, G. Sparacino (2010) “Human brain hemodynamic activity elicited by visual short–term memory in functional near infrared spectroscopy (fNIRS) assessed by a Bayesian filtering approach”. Functional Near Infrared Spectroscopy: 2010, Harvard University, Cambridge, MA, October 15 – 17, pp. 61

S. Cutini, F. Scarpa, P. Scatturin, R. Dell’Acqua, M. Zorzi (2010) “Neural correlates of numerical cognition: An fNIRS investigation”. Functional Near Infrared Spectroscopy: 2010, Harvard University, Cambridge, MA, October 15 – 17, pp. 53

A. Ruggeri, F. Scarpa (2008) “Automatic Estimation of Keratocyte Density in Confocal Microscopy of the Cornea”. ARVO annual meeting, Fort Lauderdale, Florida, USA, April 27 – May 1, n. 3929

A. Ruggeri, F. Scarpa, E. Grisan, J.W. McLaren, J.C. Erie, W.M. Bourne (2007) “Evaluation of automatic corneal nerve tracing in normal and refractive surgery subjects”. ARVO annual meeting, Fort Lauderdale, Florida, USA, May 6 – 10, pp. 2753

A. Ruggeri, F. Scarpa, E. Grisan (2006) “Automatic Tracing of Subbasal Nerves in Confocal Microscopy Images”. ARVO annual meeting, Fort Lauderdale, Florida, USA, April 30 – May 4, pp. 1338

F. Scarpa, E. Grisan, A. Ruggeri (2006) “Automatic detection and measurement of sub–basal nerves in confocal microscopy of the cornea”. 18th Annual Meeting European Eye Bank Association, Venice, Italy, January 20 – 21, pp. 69


Abstracts in national conference proceedings:

G. Nanto, A. Berto, L. Dall'Olmo, C. Ciolfi, F. Scolaro, M. Alaibac, S. Mocellin , A. Galgaro, F. Scarpa (2023) “3D moles mapping and analysis for automatic melanoma detection”. VIII Congress of the National Group of Bioengineering (GNB), Padova, Italy, 21 – 23 June.

A. Colonna, F. Scarpa, A. Ruggeri (2021) “Automatic estimation of nerve tortuosity in corneal images”. VII Congress of the National Group of Bioengineering (GNB), Trieste, Italy, 9 – 11 June

F. Scarpa, A. Ruggeri (2014) “Automatic grading of nerves tortuosity from in-vivo confocal images of the cornea”. IV Congress of the National Group of Bioengineering (GNB), Pavia, Italy, 25 – 27 June, pp. M–17

C. Fabris, F. Scarpa, S. Brigadoi, S. Cutini, P. Scatturin, R. Dell’Acqua, G. Sparacino (2012) “Estimation of the stimulus–evoked hemodynamic response from fNIRS measurements”. III Congress of the National Group of Bioengineering (GNB), Roma, Italy, 26 – 29 June, pp. 274–275

F. Scarpa, S. Cutini, L. Garbin, P. Scatturin, C. D’Avanzo, R. Dell’Acqua, G. Sparacino (2010) “A Bayesian filtering approach to estimate hemodynamic response in functional near infrared spectroscopy (fNIRS)”. II Congress of the National Group of Bioengineering (GNB), Torino, Italy, 8 – 10 July, pp. 553–554

F. Scarpa, M. De Luca, A. Ruggeri (2010) “A system for the automatic estimation of morphometric parameters of corneal endothelium”. II Congress of the National Group of Bioengineering (GNB), Torino, Italy, 8 – 10 July, pp. 555–556

F. Scarpa, E. Grisan, A. Ruggeri (2008) “Automatic Tracing of Nerves in Confocal Images of the Cornea”. I Congress of the National Group of Bioengineering (GNB), Pisa, Italy, 3 – 5 July, pp. 649–650



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