Publications 

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In Journals 

    2021

  1. S. Battaglin, M.G. Pedersen
    Geometric analysis of mixed-mode oscillations in a model of electrical activity in human beta-cells
    Nonlinear Dynamics, 104: 4445–4457 (2021)
    doi: 10.1007/s11071-021-06514-z
    ReadCube

  2. M.G. Pedersen, M. Meneghini
    Data-driven estimation of change points reveals correlation between face mask use and accelerated curtailing of the first wave of the COVID-19 epidemic in Italy
    Infectious Diseases, 53: 243-251 (2021)
    doi: 10.1080/23744235.2021.1877810

    2020

  3. J.M. Rodriguez-Llanes, R. Castro Delgado, M.G. Pedersen, M. Meneghini, P. Arcos González
    Surging critical care capacity for COVID-19: Key now and in the future
    Progress in Disaster Science, 8, art. no. 100136 (2020)
    doi: 10.1016/j.pdisas.2020.100136

  4. F. Montefusco, G. Cortese, M.G. Pedersen
    Heterogeneous alpha-cell population modeling of glucose-induced inhibition of electrical activity
    Journal of Theoretical Biology, 485, art. no. 110036 (2020).
    doi: 10.1016/j.jtbi.2019.110036
    Preprint

    2019

  5. F. Montefusco, M.G. Pedersen
    From local to global modeling for characterizing calcium dynamics and their effects on electrical activity and exocytosis in excitable cells
    International Journal of Molecular Sciences, 20, art. no. 6057 (2019).
    doi: 10.3390/ijms20236057
    PDF

  6. I.M. Bulai, M.G. Pedersen
    Stopping waves: Geometric analysis of coupled bursters in an asymmetric excitation field
    Nonlinear Dynamics, 96: 1927-1937 (2019).
    doi: 10.1007/s11071-019-04895-w
    Readcube: https://rdcu.be/bstHw

    Preprint

  7. M.G. Pedersen, A. Tagliavini, J.-C. Henquin
    Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification: experiments and modeling
    American Journal of Physiology - Endocrinology and Metabolism, 316: E475-E486 (2019).
    doi: 10.1152/ajpendo.00380.2018
    Preprint

    2018

  8. I.M. Bulai, M.G. Pedersen
    Hopf bifurcation analysis of the fast subsystem of a polynomial phantom burster model
    Dolomites Research Notes on Approximation, 11: 3-10 (2018).
    doi: 10.14658/pupj-drna-2018-3-2

  9. F. Montefusco, M.G. Pedersen
    Explicit theoretical analysis of how the rate of exocytosis depends on local control by Ca2+ channels
    Computational and Mathematical Methods in Medicine, Art. no. 5721097 (2018).
    doi: 10.1155/2018/5721097
    Preprint

  10. N. Lago, N. Wrachien, M.G. Pedersen, A. Cester
    Simultaneous stimulation and recording of cell activity with reference-less sensors: Is it feasible?
    Organic Electronics, 62:676-684 (2018).
    doi: 10.1016/j.orgel.2018.07.007

  11. N. Lago, M. Buonomo, S. Imran, R. Bertani, N. Wrachien, M. Bortolozzi, M.G. Pedersen, A. Cester
    TIPS-pentacene as biocompatible material for solution processed high performance electronics operating in water
    IEEE Electron Device Letters, 39:1401-1404 (2018).
    doi: 10.1109/LED.2018.2856462

  12. A. Loppini, M.G. Pedersen
    Gap-junction coupling can prolong beta-cell burst period by an order of magnitude via phantom bursting
    Chaos, 28:063111 (2018).
    doi: 10.1063/1.5022217
    Preprint

  13. M.G. Pedersen.
    Biological mechanisms beyond network analysis via mathematical modeling: Comment on "Network science of biological systems at different scales: A review" by Marko Gosak et al.
    Physics of Life Reviews, 24:156-158 (2018).
    doi: 10.1016/j.plrev.2017.12.001

    2017

  14. A. Loppini, M.G. Pedersen, M. Braun, S. Filippi.
    Gap-junction coupling and KATP channels in human beta-cell clusters: Effects on emergent dynamics
    Physical Review E, 96:032403 (2017).
    doi: 10.1103/PhysRevE.96.032403

  15. F. Montefusco, A. Tagliavini, M. Ferrante, M.G. Pedersen
    Concise Whole-Cell Modeling of BKCa-CaV Activity Controlled by Local Coupling and Stoichiometry
    Biophysical Journal, 112:2387-2396 (2017).
    doi: 10.1016/j.bpj.2017.04.035
    Preprint
    Supplementary Material

  16. N.R. Gandasi, P.Yin, M. Riz, M.V. Chibalina, G. Cortese, P.-E. Lund, V. Matveev, P. Rorsman, A. Sherman, M.G. Pedersen, S. Barg
    Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
    The Journal of Clinical Investigation, 127:2353-2364 (2017).
    doi: 10.1172/JCI88491

  17. A. Edlund, M.G. Pedersen, A. Lindqvist, N. Wierup, M. Flodstrom-Tullberg, L. Eliasson
    CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
    Scientific Reports, 7:90 (2017).
    doi: 10.1038/s41598-017-00098-8

  18. A. Tagliavini, M.G. Pedersen:
    Spatiotemporal Modeling of Triggering and Amplifying Pathways in GLP-1 Secreting Intestinal L Cells
    Biophysical Journal, 112:162-171 (2017).
    doi: 10.1016/j.bpj.2016.11.3199

  19. M.G. Pedersen, A. Tagliavini, G. Cortese, M. Riz, F. Montefusco:
    Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells
    Mathematical Biosciences, 283:60-70 (2017).
    doi: 10.1016/j.mbs.2016.11.010
    Preprint

    2016

  20. G. Cortese, N. Gandasi, S. Barg, M.G. Pedersen:
    Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules is Impaired in Human Diabetic beta-cells
    PLoS ONE, 11:e0167282 (2016).
    doi: 10.1371/journal.pone.0167282
    Preprint

  21. M.G. Pedersen, I. Ahlstedt, M. ElHachmane, S. Gopel:
    Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells.
    Scientific Reports, 6: 31214 (2016)
    doi: 10.1038/srep31214
    Preprint
    Supplementary Information
    MATLAB code

  22. G. Cappon, M.G. Pedersen:
    Heterogeneity and nearest-neighbor coupling can explain small-worldness and wave properties in pancreatic islets
    Chaos, 26:053103 (2016)
    doi: 10.1063/1.4949020
    Preprint

  23. A. Tagliavini, J. Tabak, R. Bertram, M.G. Pedersen:
    Is Bursting More Effective than Spiking in Evoking Pituitary Hormone Secretion? A Spatiotemporal Simulation Study of Calcium and Granule Dynamics
    American Journal of Physiology - Endocrinology and Metabolism, 310:E515-E525 (2016).
    doi: 10.1152/ajpendo.00500.2015

    2015

  24. S. Antonucci, A. Tagliavini, M.G. Pedersen:
    Reactive oxygen and nitrogen species disturb Ca2+ oscillations in insulin-secreting MIN6 beta-cells
    Islets, 7(4):e1107255 (2015).
    doi: 10.1080/19382014.2015.1107255

  25. M. Riz, M.G. Pedersen:
    Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
    PLoS Computational Biology, 11(12):e1004600 (2015).
    doi: 10.1371/journal.pcbi.1004600
    Preprint

  26. A. Loppini, M. Braun, S. Filippi, M.G. Pedersen:
    Mathematical modeling of gap junction coupling and electrical activity in human beta-cells
    Physical Biology, 12(6):066002 (2015).
    doi: 10.1088/1478-3975/12/6/066002

  27. F. Montefusco, M.G. Pedersen:
    Mathematical modelling of local calcium and regulated exocytosis during inhibition and stimulation of glucagon secretion from pancreatic alpha-cells
    Journal of Physiology, 593:4519-4530 (2015).
    doi: 10.1113/JP270777
    MATLAB code (zip-file)

  28. M. Riz, M. Braun, X. Wu, M.G. Pedersen:
    Inwardly rectifying Kir2.1 currents in human beta-cells control electrical activity: Characterisation and mathematical modelling
    Biochemical and Biophysical Research Communications, 459:284-287 (2015).
    doi: 10.1016/j.bbrc.2015.02.099
    XPPAUT ode-file

  29. A.M. Bersani, E. Bersani, G. Dell'Acqua, M.G. Pedersen:
    New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper .
    Continuum Mechanics and Thermodynamics 27:659-684 (2015).
    doi: 10.1007/s00161-014-0367-4

    2014

  30. M.G. Pedersen, V.A. Salunkhe, E. Svedin, A. Edlund, L. Eliasson:
    Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.
    PLoS One, 9:e103874 (2014).
    doi: 10.1371/journal.pone.0103874

  31. C. Cobelli, C. Dalla Man, M.G. Pedersen, A. Bertoldo, G. Toffolo:
    Advancing our Understanding of the Glucose System via Modeling: A Perspective
    IEEE Transactions on Biomedical Engineering, 61:1577-1592 (2014).
    doi: 10.1109/TBME.2014.2310514

  32. M. Riz, M.G. Pedersen, G.M. Toffolo, G. Haschke, H.-C. Schneider, T. Klabunde, D. Margerie, C. Cobelli
    Minimal modeling of insulin secretion in the perfused rat pancreas: a drug effect case study
    American Journal of Physiology - Endocrinology and Metabolism, 306:E627-E634 (2014).
    doi:10.1152/ajpendo.00603.2013

  33. M. Riz, M. Braun, M.G. Pedersen:
    Mathematical Modeling of Heterogeneous Electrophysiological Responses in Human beta-cells
    PLoS Computational Biology, 10(1):e1003389 (2014)
    doi:10.1371/journal.pcbi.1003389
    Preprint
    XPPAUT ode-file (Figs. 1-5)
    XPPAUT ode-file (Fig. 6)

    2013

  34. M.G. Pedersen, E. Mosekilde, K.S. Polonsky, D.S. Luciani:
    Complex patterns of metabolic and Ca2+ entrainment in pancreatic islets by oscillatory glucose
    Biophysical Journal 105:29-39 (2013)
    doi: 10.1016/j.bpj.2013.05.036.
    XPPAUT ode-file

  35. M.G. Pedersen, C. Cobelli:
    Multiscale modelling of insulin secretion during an intravenous glucose tolerance test
    Interface Focus, 3:20120085 (2013)
    doi: 10.1098/rsfs.2012.0085
    Preprint
    XPPAUT ode-file

    2012

  36. A.H. Rosengren, M. Braun, T. Mahdi, S.A. Andersson, M.E. Travers, M. Shigeto, E. Zhang, P. Almgren, C. Ladenvall, A.S. Axelsson, A. Edlund, M.G. Pedersen, A. Jonsson, R. Ramracheya, Y. Tang, J.N. Walker, A. Barrett, P.R. Johnson, V. Lyssenko, M.I. McCarthy, L. Groop, A. Salehi, A.L. Gloyn, E. Renstrom, P. Rorsman, L. Eliasson.
    Reduced Insulin Exocytosis in Human Pancreatic beta-Cells With Gene Variants Linked to Type 2 Diabetes.
    Diabetes 61:1726-1733 (2012)
    doi:10.2337/db11-1516

  37. A. Basu, M.G. Pedersen, C. Cobelli:
    Prediabetes: Evaluation of beta-cell function.
    Diabetes 61:270-271 (2012)
    doi:10.2337/db11-1677

    2011

  38. M.G. Pedersen, G. Cortese, L. Eliasson:
    Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in beta-cells from mice and humans
    Progress in Biophysics and Molecular Biology 107:257-264 (2011)
    doi:10.1016/j.pbiomolbio.2011.07.012
    XPPAUT ode-file

  39. M.G. Pedersen, C. Dalla Man, C. Cobelli:
    Multiscale modeling of insulin secretion
    IEEE Transactions on Biomedical Engineering 58:3020-3023 (2011)
    doi:10.1109/TBME.2011.2164918

  40. M.G. Pedersen:
    On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls
    Biophysical Journal 101:793-802 (2011)
    doi:10.1016/j.bpj.2011.06.061

  41. S. Andersson, M.G. Pedersen, J. Vikman, L. Eliasson:
    Glucose-dependent docking and SNARE-protein mediated exocytosis in mouse pancreatic alpha-cell
    Pflugers Archiv - European Journal of Physiology 462:443-454 (2011)
    doi:10.1007/s00424-011-0979-5

    2010

  42. M.G. Pedersen:
    A biophysical model of electrical activity in human beta-cells.
    Biophysical Journal 99:3200-3207 (2010).
    doi:10.1016/j.bpj.2010.09.004
    Preprint
    XPPAUT ode-file

  43. M.G. Pedersen:
    Insulin secretory granules enter a highly calcium-sensitive state following palmitate-induced dissociation from calcium channels - a theoretical study.
    Journal of Neuroendocrinology 22:1315-1324 (2010).
    doi:10.1111/j.1365-2826.2010.02056.x

  44. K. Tsaneva-Atanasova, H.M. Osinga, J. Tabak, M.G. Pedersen:
    Modeling Mechanisms of Cell Secretion.
    Acta Biotheoretica 58:315-327 (2010).
    doi:10.1007/s10441-010-9115-8

  45. M.G. Pedersen, G.M.Toffolo, C. Cobelli:
    Cellular modeling: insight into oral minimal models of insulin secretion.
    American Journal of Physiology - Endocrinology and Metabolism 298:E597-E601 (2010).
    doi:10.1152/ajpendo.00670.2009
    XPPAUT ode-file

  46. M.G. Pedersen, A.M. Bersani:
    Introducing Total Substrates  Simplifies Theoretical Analysis at Non-Negligible Enzyme Concentrations: Pseudo First-Order Kinetics and the Loss of Zero-Order Ultrasensitivity.
    Journal of Mathematical Biology 60:267-283 (2010).
    doi:10.1007/s00285-009-0267-6

  47. 2009

  48. M.G. Pedersen, A. Sherman:
    Newcomer insulin secretory granules as a highly calcium sensitive pool.
    Proceedings of the National Academy of Sciences of the U.S.A. (PNAS) 106:7432-7436 (2009).
    doi:10.1073/pnas.0901202106
    XPPAUT ode-file (1) , XPPAUT ode-file (2)

  49. M.G. Pedersen.
    Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion.
    Journal of Diabetes Science and Technology 3:12-20 (2009).  [Invited review].
    doi:10.1177/193229680900300103

    2008

  50. M.G. Pedersen, A. Corradin, G.M. Toffolo, C. Cobelli. 
    A subcellular model of pancreatic insulin secretion.
    Philosophical Transactions of the Royal Society A 13:3525-3543 (2008).
    doi:10.1098/rsta.2008.0120
    XPPAUT ode-file

  51. M.G. Pedersen, M.P. Sørensen. 
    Wave-Block Due to a Threshold Gradient Underlies Limited Coordination in Pancreatic Islets.
    Journal of Biological Physics 34:425–432 (2008).
    doi:10.1007/s10867-008-9069-0

  52. M.G. Pedersen, A.M. Bersani, E. Bersani. 
    Quasi Steady-State Approximations in Signal Transduction -- a Word of Caution.
    Journal of Mathematical Chemistry 43:1318-1344 (2008).
    doi:10.1007/s10910-007-9248-4

  53. M.G. Pedersen, A.M. Bersani, E. Bersani, G. Cortese.
    The total quasi-steady state approximation for complex enzyme reactions.
    Mathematics and Computers in Simulation (MATCOM) 79:1010–1019 (2008).
    doi:10.1016/j.matcom.2008.02.009 

  54. 2007

  55. M.G. Pedersen. 
    Phantom bursting is highly sensitive to noise and unlikely to account for slow bursting in beta-cells: Considerations in favor of metabolically driven oscillations.
    Journal of Theoretical Biology 248:391-400 (2007).
    doi:10.1016/j.jtbi.2007.05.034

  56. R. Bertram, L. Satin, M.G. Pedersen, D. Luciani, A. Sherman. 
    Interaction of Glycolytic and Mitochondrial Dynamics Drives Diverse Patterns of Calcium Oscillations in Pancreatic beta-Cells.
    Biophysical Journal 92:1544-1555 (2007).
    doi:10.1529/biophysj.106.097154

  57. M.G. Pedersen, A.M. Bersani, E. Bersani. 
    The Total Quasi-Steady-State Approximation for Fully Competitive Enzyme Reactions.
    Bulletin of Mathematical Biology 69:433-457 (2007).
    doi:10.1007/s11538-006-9136-2

  58. M.G. Pedersen, M.P. Sørensen.
    The effect of noise on beta-cell burst period.
    SIAM Journal of Applied Mathematics. 67:530-542 (2007).
    doi:10.1137/060655663

  59. 2006

  60. R. Bertram, M.G. Pedersen, D.S. Luciani, A. Sherman.
    A Simplified Model for Mitochondrial ATP Production.
    Journal of Theoretical Biology 243:575-586 (2006).
    doi:10.1016/j.jtbi.2006.07.019

    2005

  61. M.G. Pedersen, R. Bertram, A. Sherman. 
    Intra- and Inter-islet Synchronization of Metabolically Driven Insulin Secretion.
    Biophysical Journal 89:107-119 (2005).
    doi:10.1529/biophysj.104.055681

  62. M.G. Pedersen. 
    A Comment on Noise Enhanced Bursting in Pancreatic beta-cells.
    Journal of Theoretical Biology 235:1-3 (2005).
    doi:10.1016/j.jtbi.2005.01.025

  63. M.G. Pedersen. 
    Wave speeds of solutions to density dependent nonlinear Nagumo diffusion equations - inspired by oscillating gap-junction conductance in the pancreatic islets of Langerhans.
    Journal of Mathematical Biology 50:683-698 (2005).
    doi:10.1007/s00285-004-0304-4

  64. 2004

  65. M.G. Pedersen. 
    Homogenization of heterogeneously coupled bistable ODE's - applied to excitation waves in pancreatic islets of Langerhans.
    Journal of Biological Physics 30:285-303 (2004).
    doi:10.1023/B:JOBP.0000046727.28337.f4

  66. A. De Gaetano, G. Cortese, M.G. Pedersen, S. Panunzi, U. Picchini, A. Morelli.
    Modeling Serum Creatinine in Septic ICU Patients.
    Cardiovascular Engineering - An International Journal 4:173-180 (2004).
    doi:10.1023/B:CARE.0000031546.79563.bd


    In Refereed Conference Proceedings:

  67. A.M. Bersani, M.G. Pedersen, E. Bersani, F. Barcellona.
    A mathematical approach to the study of signal transduction pathways in MAPK cascade
    in: Applied and Industrial Mathematics in Italy. Proceedings of the 7th Conference. Venice, Italy 20 - 24 September 2004.
    Primicerio, M., Spigler, R., Valente V. (eds.)
    World Scientific, Singapore (2005). 

    Book chapters

  68. G.M. Toffolo, M.G. Pedersen, C. Cobelli.
    Whole-body and cellular models of glucose-stimulated insulin secretion
    in: BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic beta-Cells .
    Booss-Bavnbek, B.; Klosgen, B.; Larsen, J.; Pociot, F.; Renstrom, E. (Eds.)
    PDF

    Theses

  69. M.G. Pedersen. 
    Dynamics and Synchrony of Pancreatic beta-cells and Islets.
    Ph.D. thesis. 
    Department of Mathematics. Technical University of Denmark. June 2006.
    PDF

  70. M.G. Pedersen. 
    Mirror symmetry - the SYZ conjecture.
    Master (M.Sc.) thesis.
    Department of Mathematics. University of Copenhagen. January 2002.

  71. T. M. Carlsen, D. Zeuthen, M.G. Pedersen. 
    Souslinoperationen i målteori og topologi (The Souslin-operation in measure theory and topology).
    Bachelor (B.Sc.) thesis (in Danish).
    Department of Mathematics. University of Copenhagen. June 1999.