Modeling, Identification and Control of Physiological Systems

Research activities:

  • Development and validation of “Minimal" models of the glucose system to measure signals and parameters (such insulin sensitivity, beta-cell function, hepatic insulin extraction, hepatic glucose production, glucose utilization and rate of appearance of ingested glucose) from intravenous/oral tolerance tests.
  • Development and validation of "Maximal" models of the glucose-insulin system for in silico simulation.
  • Development and validation of Models of the glucose-insulin system for use in control applications (artificial pancreas).
  • Development of Models for quantitative assessment of glucose kinetics at organ level (skeletal muscle).
  • PK-PD Models of antidiabetic drugs and new insulin molecules.

Homepage: bio.dei.unipd.it

People: Claudio Cobelli (contact person), Alessandra Bertoldo, Simone Del favero, Chiara Dalla Man.

  • Parameter estimation techniques at both the individual and population level (nonlinear-mixed effects)
  • Deconvolution techniques for biomedical signals analysis

Homepage: bio.dei.unipd.it

People: Claudio Cobelli (contact person), Alessandra Bertoldo, Giovanni Sparacino, Chiara Dalla Man.

  • Development of control algorithms for automatic insulin delivery in type 1 diabetes (Artificial Pancreas): personalization, run2run adaptation, fault detection and fault compensation for safe unsupervised AP use.
  • In silico validation and clinical testing of AP algorithms.

Homepage: bio.dei.unipd.it

People: Claudio Cobelli (contact person), Chiara Dalla Man, Simone Del Favero, Andrea Facchinetti.