Functional and Anatomical Imaging Research

Research activities:

  • Development of novel models and estimation methods for quantitative PET imaging: compartmental models, input/output models, Variational Bayesian methods for voxel-wise quantification, Non-linear mixed effect modelling approach, Multi-scale hierarchical approaches for parametric mapping.
  • Quantification of PET data to evaluate system impairments in clinical conditions: evaluation of microglial activity in people at ultra high risk of psychosis and in schizophrenia with [11C]PBR28; quantification of [18F]FDG images in patients with acute lung injury; models and parametric imaging of ¹?F-fluoro-3-deoxy-3-L-fluorothymidine PET data to investigate tumour heterogeneity; study of glucose delivery, transport, and phosphorylation in skeletal muscle in obesity and type 2 Diabetes.
  • Correlation of brain mRNA and imaging data : the genomic plot to estimate the specific and non-displaceable components fraction; MENGA: a new comprehensive tool for the integration of neuroimaging data and the mRNA information.
  • Arterial input function modeling studies and alternative non-invasive input function approaches.

Homepage: http://fair.dei.unipd.it

People: Alessandra Bertoldo (contact person)

  • Functional magnetic resonance imaging (fMRI): functional connectivity, dynamic causal modelling to study the effective connectivity during tasks or in resting state; assessment of cerebral hemodynamic impairment thought fMRI data analysis, methods to integrate EEG & fMRI.
  • Perfusion: deconvolution methods for quantification of perfusion for Dynamic Susceptibility Contrast MRI, sequence development for Arterial Spin Labeling (ASL); Look-Locker ASL, Hadamard Encoded ASL; novel methods and models for quantification of perfusion using dynamic Arterial Spin Labelling imaging.
  • Diffusion: models for improved analysis of multi-shell diffusion MRI data; sequence development for DTI in skeletal muscle, models to quantify DTI data in skeletal muscle; Evaluation of brain damage in Multiple Sclerosis using multi-shell diffusion MRI data.
  • Susceptibility: Susceptibility weighted imaging (SWI), Quantitative Susceptibility Mapping (QSM); development of novel methods for quantification of magnetic susceptibility.
  • Morphological: automatic multiple sclerosis lesion detection in gray matter by combining DIR and FLAIR images.

Homepage: http://fair.dei.unipd.it

People: Alessandra Bertoldo (contact person)

  • Small joint morphology: detection of markers from 2D and 3D images of the small joints. Automatic assessment of synovial shape and dimension
  • Synovial perfusion: perfusion identification and modelling of the local perfusion within the synovia. Detection and characterization of perfusion patterns linked to different underlying diseases or substrates. Develop methods for an accurate differential diagnosis of rheumatic diseases based on the perfusion patterns and imaging biomarkers.
  • Prenatal and pediatric ultrasound: automatic methods for the analysis of 2D+t and 3D+T images of prenatal and pediatric ultrasound. Development of methods for the following up of imaging biomarkers at different examination during the fetus/children life. Analysis of the relationship between vessel-wall alterations and the risk of cardiovascular events and diabetes in later life.

Homepage: http://fair.dei.unipd.it

People: Enrico Grisan (contact person)

  • Confocal microendoscopy in Barrett’s esophagus: methods for the evaluation of the cellular architecture and of the functional and morphological alterations of the esophageal mucosa. Identification and classification of mucosal alterations (gastric metaplasia, intestinal metaplasia, high grade displasia, neoplasia) to provide a target for biopsies and quantitative markers for cancer surveillance.
  • Confocal microendoscopy in celiac disease: develop tools and methods for the quantitative evaluation and staging of the intestinal mucosa alterations typical of celiac disease, in order to evaluate the severity and the therapeutic/diet effectiveness.
  • White Light/NBI endoscopy: develop tools and methods to provide computer-aided system for the detection of metaplastic and neoplastic tissues in white light and NBI endoscopic images.
  • Confocal microscopy: methods for the quantitative extraction of relevant information of protein/gene expression and signaling activation from fluorescent confocal microscopy of animal models (especially zebrafish). Develop tools for the registration of image stacks to reference atlases.

Homepage: http://fair.dei.unipd.it

People: Enrico Grisan (contact person)